| | City | Population |
| 1. | Managua | 973,087 |
| 2. | Leon | 144,538 |
| 3. | Masaya | 130,113 |
| 4. | Tipitapa | 127,153 |
| 5. | Chinandega | 126,387 |
| 6. | Matagalpa | 109,089 |
| 7. | Esteli | 96,422 |
| 8. | Granada | 89,409 |
| 9. | Ciudad Sandino | 70,013 |
| 10. | Juigalpa | 54,731 |
| 11. | El Viejo | 53,504 |
| 12. | Nueva Guinea | 52,929 |
| 13. | Jinotega | 51,073 |
| 14. | Bluefields | 44,373 |
| 15. | Diriamba | 35,008 |
| 16. | Ocotal | 33,928 |
| 17. | Puerto Cabezas | 33,635 |
| 18. | Chichigalpa | 33,137 |
| 19. | Rivas | 30,293 |
| 20. | San Rafael del Sur | 29,836 |
| 21. | Jinotepe | 29,507 |
| 22. | Boaco | 29,046 |
| 23. | Nagarote | 26,270 |
| 24. | Jalapa | 24,037 |
| 25. | La Paz Centro | 23,481 |
| 26. | San Marcos | 23,347 |
| 27. | Masatepe | 21,452 |
| 28. | Nandaime | 20,810 |
| 29. | Rama | 20,456 |
| 30. | Somoto | 20,316 |
| 31. | Corinto | 19,183 |
| 32. | Rio Blanco | 17,018 |
| 33. | Camoapa | 16,653 |
| 34. | El Crucero | 16,469 |
| 35. | Siuna | 16,056 |
| 36. | Somotillo | 15,385 |
| 37. | Santo Tomas | 14,809 |
| 38. | Quilali | 13,590 |
| 39. | San Carlos | 13,451 |
| 40. | Ciudad Dario | 13,318 |
| 41. | Ticuantepe | 13,209 |
| 42. | El Sauce | 11,898 |
| 43. | Condega | 11,000 |
| 44. | Acoyapa | 10,563 |
| 45. | Matiguas | 10,523 |
| 46. | Diriomo | 10,113 |
| 47. | Telica | 8,776 |
| 48. | San Lorenzo | 8,694 |
| 49. | Corn Island | 8,011 |
| 50. | Bocana de Paiwas | 7,872 |
| 51. | Villa Sandino | 7,799 |
| 52. | San Juan del Sur | 7,790 |
| 53. | Niquinohomo | 7,732 |
| 54. | Larreynaga | 7,703 |
| 55. | Puerto Morazan | 7,671 |
| 56. | San Jorge | 7,158 |
| 57. | Nindiri | 7,073 |
| 58. | Dolores | 7,065 |
| 59. | Wiwili | 6,955 |
| 60. | La Concepcion | 6,946 |
| 61. | Nandasmo | 6,934 |
| 62. | Laguna de Perlas | 6,809 |
| 63. | Waslala | 6,498 |
| 64. | Posoltega | 6,403 |
| 65. | Waspam | 6,403 |
| 66. | Bonanza | 6,315 |
| 67. | El Realejo | 6,208 |
| 68. | Santo Domingo | 5,827 |
| 69. | Santa Teresa | 5,789 |
| 70. | San Rafael del Norte | 5,458 |
| 71. | Belen | 5,415 |
| 72. | El Ayote | 5,406 |
| 73. | Potosi | 5,222 |
| 74. | Carlos Fonseca Amador | 5,219 |
| 75. | Tisma | 5,182 |
| 76. | San Juan de Limay | 4,997 |
| 77. | Muy Muy | 4,839 |
| 78. | Pueblo Nuevo | 4,608 |
| 79. | San Sebastian de Yali | 4,514 |
| 80. | Teustepe | 4,287 |
| 81. | San Miguelito | 4,181 |
| 82. | Moyogalpa | 3,940 |
| 83. | San Dionisio | 3,910 |
| 84. | Diria | 3,903 |
| 85. | San Fernando | 3,899 |
| 86. | San Juan de Rio Coco | 3,820 |
| 87. | Palacaguina | 3,678 |
| 88. | Muelle de los Bueyes | 3,587 |
| 89. | Achuapa | 3,299 |
| 90. | La Libertad | 3,127 |
| 91. | El Rosario | 2,991 |
| 92. | Santa Rosa del Penon | 2,913 |
| 93. | San Ramon | 2,827 |
| 94. | Altagracia | 2,771 |
| 95. | El Almendro | 2,681 |
| 96. | Tola | 2,638 |
| 97. | La Paz de Oriente | 2,454 |
| 98. | Cuapa | 2,400 |
| 99. | San Jose de Bocay | 2,367 |
| 100. | Mozonte | 2,338 |
The Source for World Rankings